Recombinant human HMGA2 protein
HMGA2 is a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Recombinant human HMGA2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
High mobility group AT-hook 2, BABL, HMGI-C, HMGIC, LIPO, STQTL9
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
12.8 kDa (117aa)
Additionnal Information
References & Citations
D'Angelo, D.., et al. (2012) J. Clin. Endocrinol. Metab. 97 (7), E1128-E1138 Helmke, B.M., et al. (2012) Anticancer Res. 32 (5), 1589-1593
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT, 250 mM Imidazole
Scientific Category
Metabolism
NCBI Accession Number
NP_003474.1
Uniprot Accession Number
P52926
Species
Human
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