Recombinant human BMP-6 protein

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, BMP6 has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. Recombinant human BMP6 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Bone morphogenetic protein 6, BMP6, VG-1-related protein, VG-1-R, VGR-1, VGR

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

18 kDa (164aa) confirmed by MALDI-TOF

Additionnal Information

BMP6, ATGP2090-10 µg, ATGP2090-20 µg, ATGP2090-50 µg, ATGP2090-100 µg, ATGP2090-250 µg, ATGP2090-500 µg, ATGP2090-1 mg, ATGP2090-10, ATGP2090-20, ATGP2090-50, ATGP2090-100, ATGP2090-250, ATGP2090-500, ATGP2090-1

References & Citations

Ebisawa T, Tada K, et al. (1999) . J Cell Sci. 112 (Pt 20) :3519-27.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 10 mM Sodium Citrate buffer (pH 3.5) containing 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_001709

Uniprot Accession Number

P22004

Species

Human

AA Sequence

MSASSR RRQQSRNRST QSQDVARVSS ASDYNSSELK TACRKHELYV SFQDLGWQDW IIAPKGYAAN YCDGECSFPL NAHMNATNHA IVQTLVHLMN PEYVPKPCCA PTKLNAISVL YFDDNSNVIL KKYRNMVVRA CGCH