Recombinant human Arylsulfatase A/ARSA protein
ARSA hydrolyzes cerebrosidesulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. Recombinant human ARSA protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
ASA, Cerebroside-sulfatase, metachromatic leucodystrophy (MLD)
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
54.3 kDa (512aa)
Additionnal Information
References & Citations
Matthes, F., et al. (2011) J. Biol. Chem. 286 (20), 17487-17494; ; Hayashi, T., et al. (2011) Psychiatry Clin. Neurosci. 65 (1), 105-108
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol
Scientific Category
Metabolism
NCBI Accession Number
NP_000478.3
Uniprot Accession Number
P15289
Species
Human
AA Sequence
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