Recombinant human PDZK1 protein
PDZK1 is a PDZ domain-containing scaffolding protein. This protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Recombinant human PDZK1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Na (+) /H (+) exchange regulatory cofactor NHE-RF3, Na (+) /H (+) exchange regulatory cofactor NHE-RF3, CAP70, CLAMP, NHERF-3, NHERF3, PDZD1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
59 kDa (542aa)
Additionnal Information
References & Citations
Kocher O, Yesilaltay A, et al. (2003) . J Biol Chem. 278 (52) :52820-5.; ; Inoue J, Otsuki T, et al. (2004) . Am J Pathol. 165 (1) :71-81.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Metabolism
NCBI Accession Number
NP_001188254
Uniprot Accession Number
Q5T2W1
Species
Human
AA Sequence
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