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Recombinant mouse CCL2/MCP-1 protein

Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1) . CCL2 recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Recombinant mouse CCL2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Chemokine (C-C motif) ligand 2, Monocyte chemoattractant protein 1, Monocyte chemotactic protein 1, MCP-1, Platelet-derived growth factor-inducible protein JE, Small-inducible cytokine A2, Je, Mcp1, Scya2, HC11, MCAF, Sigje, SMC-CF

Expression System

E.coli

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

16 kDa (146aa) confirmed by MALDI-TOF

Additionnal Information

CCL2, JE, MCP1, ATGP2074-10 µg, ATGP2074-20 µg, ATGP2074-50 µg, ATGP2074-100 µg, ATGP2074-250 µg, ATGP2074-500 µg, ATGP2074-1 mg, ATGP2074-10, ATGP2074-20, ATGP2074-50, ATGP2074-100, ATGP2074-250, ATGP2074-500, ATGP2074-1

References & Citations

Foresti ML, Arisi GM, et al. (2009) . J Neuroinflammation. 6:40.; ; Semple BD, Bye N, et al. (2010) . J Cereb Blood Flow Metab. 30 (4) :769-82.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_035463

Uniprot Accession Number

P10148

Species

Mouse

AA Sequence

QPDAVNAPL TCCYSFTSKM IPMSRLESYK RITSSRCPKE AVVFVTKLKR EVCADPKKEW VQTYIKNLDR NQMRSEPTTL FKTASALRSS APLNVKLTRK SEANASTTFS TTTSSTSVGV TSVTVN

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