Recombinant human JDP2 protein
Jun dimerization protein 2, also known as JDP2, is a component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. This protein is involved in a variety of transcriptional responses associated with AP-1 such as uV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. JDP2 can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JuN. It may control transcription via direct regulation of the modification of histones and the assembly of chromatin. Recombinant human JDP2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Jun dimerization protein 2, Jun dimerization protein 2, JuNDM2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
21.2 kDa (187aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Kawaida R., et al. (2003) J. Exp. Med. 197:1029-1035; ; Jin C., et al. (2006) Nat. Struct. Mol. Biol. 13:331-338;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 1mM DTT, 1mM EDTA, 250 mM imidazole
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_569736
Uniprot Accession Number
Q8WYK2
Species
Human
AA Sequence
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
PFKFB1, NT (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1, 6PF-2-K/Fru-2,6-P2ase 1, PFK/FBPase 1, 6PF-2-K/Fru-2,6-P2ase Liver Isozyme, F6PK, HL2K, MGC116715, MGC116717, PFRX) (APC) discontinued
Ring Finger Protein 34 (RNF34, Caspase Regulator CARP1, Caspases 8 and 10-associated RING Finger Protein 1, CARP-1, FLJ21786, FYVE-RING Finger Protein Momo, hRFI, Human RING Finger Homologous to Inhibitor of Apoptosis Protein hRFI, RFI, RIFF, Ring Finger Protein RIFF) (FITC)