Recombinant human JDP2 protein

Jun dimerization protein 2, also known as JDP2, is a component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. This protein is involved in a variety of transcriptional responses associated with AP-1 such as uV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. JDP2 can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JuN. It may control transcription via direct regulation of the modification of histones and the assembly of chromatin. Recombinant human JDP2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Jun dimerization protein 2, Jun dimerization protein 2, JuNDM2

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

21.2 kDa (187aa) confirmed by MALDI-TOF

Additionnal Information

JDP2, Jun dimerization protein 2, Jun dimerization protein 2, JuNDM2, ATGP2068-10 µg, ATGP2068-20 µg, ATGP2068-50 µg, ATGP2068-100 µg, ATGP2068-250 µg, ATGP2068-500 µg, ATGP2068-1 mg, ATGP2068-10, ATGP2068-20, ATGP2068-50, ATGP2068-100, ATGP2068-250, ATGP2068-500, ATGP2068-1

References & Citations

Kawaida R., et al. (2003) J. Exp. Med. 197:1029-1035; ; Jin C., et al. (2006) Nat. Struct. Mol. Biol. 13:331-338;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 1mM DTT, 1mM EDTA, 250 mM imidazole

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_569736

Uniprot Accession Number

Q8WYK2

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMMPGQI PDPSVTTGSL PGLGPLTGLP SSALTVEELK YADIRNLGAM IAPLHFLEVK LGKRPQPVKS ELDEEEERRK RRREKNKVAA ARCRNKKKER TEFLQRESER LELMNAELKT QIEELKQERQ QLILMLNRHR PTCIVRTDSV KTPESEGNPL LEQLEKK