Recombinant human ROBLD3/LAMTOR2 protein
LAMTOR2 is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Recombinant human LAMTOR2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
15.9 kDa (148aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Bohn G., et al. (2007) Nat. Med. 13:38-45; ; Sancak Y., et al. (2010) Cell. 141:290-303;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_054736
Uniprot Accession Number
Q9Y2Q5
Species
Human
AA Sequence
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