Recombinant human Galanin protein
Galanin peptides preproprotein, also known as GAL, is localized in brain pathways involved in both cognition and affect, and may inhibit learning and memory by inhibiting neurotransmitter release and neuronal firing rate. It modulates a variety of physiological processed including cognition/memory, sensory/pain processing, neurotransmitter/hormone secretion, and feeding behavior. GAL is upregulated in primary afferent and sympathetic neurones and may be involved in the development of sympathetic perineuronal baskets (rings) following nerve injury. Recombinant human GAL protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Galanin peptides preproprotein, GALN, GLNN, GMAP
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
13.9 kDa (127aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Steiner R A., et al. (2001) Proc Natl Acad Sci uSA. 4184-4189; ; Kleine B., et al. (2001) Mol Hum Reprod. 7:379-385.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT
Scientific Category
Neuroscience
NCBI Accession Number
NP_057057.2
Uniprot Accession Number
P22466
Species
Human
AA Sequence
ASAGLWS PAKEKRGWTL NSAGYLLGPH AVGNHRSFSD KNGLTSKREL RPEDDMKPGS FDRSIPENNI MRTIIEFLSF LHLKEAGALD RLLDLPAAAS SEDIERS
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