Recombinant human TMEFF1/Tomoregulin-1 protein
TMEFF1, also known as tomoregulin-1, is a type I transmembrane glycoprotein. This protein contains two follistatin modules and an EGF domain in its extracellular domain, a transmembrane domain and a short cytoplasmic tail. The extracellular domain of TMEFF1 can be released as a soluble protein. TMEFF1 is predominantly expressed in brain, but is downregulated in brain neoplasms. TMEFF1 selectively regulates nodal but not activin signaling through direct binding to the nodal co-receptor, Cripto. Recombinant human TMEFF1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Tomoregulin-1, C9orf2, CT120.1, H7365, TR-1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
33.9 kDa (314aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Gery S, Yin D, et al. (2003) . Oncogene. 22 (18) :2723-7.; ; Harms PW, et al. (2003) . Genes Dev. 17 (21) :2624-9.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol
Scientific Category
Cancer
NCBI Accession Number
NP_003683.2
Uniprot Accession Number
Q8IYR6
Species
Human
AA Sequence
Frequently Asked Questions
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