Recombinant human PRDC/GREM2 protein

GREM2 is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this protein belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this protein may play a role in regulating organogenesis, body patterning, and tissue differentiation. Recombinant human GREM2 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Gremlin-2 precursor, Gremlin-2 precursor, CKTSF1B2, DAND3, PRDC

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

19 kDa (170aa)

Additionnal Information

PRDGREM2, Gremlin-2 precursor, Gremlin-2 precursor, CKTSF1B2, DAND3, PRDC, ATGP2049-10 µg, ATGP2049-20 µg, ATGP2049-50 µg, ATGP2049-100 µg, ATGP2049-250 µg, ATGP2049-500 µg, ATGP2049-1 mg, ATGP2049-10, ATGP2049-20, ATGP2049-50, ATGP2049-100, ATGP2049-250, ATGP2049-500, ATGP2049-1

References & Citations

Sudo S, et al. (2004) . J Biol Chem. 279 (22) :23134-41.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Signal Transduction

NCBI Accession Number

NP_071914

Uniprot Accession Number

Q9H772

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSRKNRPAG AIPSPYKDGS SNNSERWQHQ IKEVLASSQE ALVVTERKYL KSDWCKTQPL RQTVSEEGCR SRTILNRFCY GQCNSFYIPR HVKKEEESFQ SCAFCKPQRV TSVLVELECP GLDPPFRLKK IQKVKQCRCM SVNLSDSDKQ