Recombinant human FAM49B protein

FAM49B has been provisionally designated FAM49B pending further characterization. In a recent genome-wide transcriptional analysis, It identified a gene signature for multiple sclerosis (MS), which reverted back to normal during pregnancy. Reversion was particularly evident for 7 genes: SOCS2, TNFAIP3, NR4A2, CXCR4, POLR2J, FAM49B, and STAG3L1, most of which encode negative regulators of inflammation. Recombinant human FAM49B protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

Protein FAM49B, Protein FAM49B, BM-009, L1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

39.1 kDa (347aa) confirmed by MALDI-TOF

Additionnal Information

FAM49B, Protein FAM49B, Protein FAM49B, BM-009, L1, ATGP2033-10 µg, ATGP2033-20 µg, ATGP2033-50 µg, ATGP2033-100 µg, ATGP2033-250 µg, ATGP2033-500 µg, ATGP2033-1 mg, ATGP2033-10, ATGP2033-20, ATGP2033-50, ATGP2033-100, ATGP2033-250, ATGP2033-500, ATGP2033-1

References & Citations

Francesca Gilli. et al. (2011) Arch Neurol. 68:879-888; ; Niranjana A Nagarajan. et al. (2012) Nature Immunology. 13:579-586.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.1M NaCl, 1mM DTT

Scientific Category

Other

NCBI Accession Number

NP_057707

Uniprot Accession Number

Q9NUQ9

Species

Human

AA Sequence

MGNLLKV LTCTDLEQGP NFFLDFENAQ PTESEKEIYN QVNVVLKDAE GILEDLQSYR GAGHEIREAI QHPADEKLQE KAWGAVVPLV GKLKKFYEFS QRLEAALRGL LGALTSTPYS PTQHLEREQA LAKQFAEILH FTLRFDELKM TNPAIQNDFS YYRRTLSRMR INNVPAEGEN EVNNELANRM SLFYAEATPM LKTLSDATTK FVSENKNLPI ENTTDCLSTM ASVCRVMLET PEYRSRFTNE ETVSFCLRVM VGVIILYDHV HPVGAFAKTS KIDMKGCIKV LKDQPPNSVE GLLNALRYTT KHLNDETTSK QIKSMLQ