Recombinant human chorionic gonadotropin subunit beta/CGB protein
CGB is a member of the glycoprotein hormone beta chain family and is the beta 3 subunit of chorionic gonadotropin (CG) . Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13. 3 and contiguous with the luteinizing hormone beta subunit gene. Recombinant human CGB protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Choriogonadotropin subunit beta precursor, CGB3, CGB5, CGB7, CGB8, Hcgb
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
17.9 kDa (168aa)
Additionnal Information
References & Citations
Andrusiewicz M, Szczerba A, et al. (2011) . J Transl Med. 9:130.; ; Gregor CR, Cerasoli E, et al. (2011) . J Biol Chem. 286 (28) :25016-26. ;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_000728
Uniprot Accession Number
P0DN86
Species
Human
AA Sequence
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