Recombinant human chorionic gonadotropin subunit beta/CGB protein

CGB is a member of the glycoprotein hormone beta chain family and is the beta 3 subunit of chorionic gonadotropin (CG) . Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13. 3 and contiguous with the luteinizing hormone beta subunit gene. Recombinant human CGB protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Choriogonadotropin subunit beta precursor, CGB3, CGB5, CGB7, CGB8, Hcgb

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

17.9 kDa (168aa)

Additionnal Information

CGB, Choriogonadotropin subunit beta precursor, CGB3, CGB5, CGB7, CGB8, Hcgb, ATGP2030-10 µg, ATGP2030-20 µg, ATGP2030-50 µg, ATGP2030-100 µg, ATGP2030-250 µg, ATGP2030-500 µg, ATGP2030-1 mg, ATGP2030-10, ATGP2030-20, ATGP2030-50, ATGP2030-100, ATGP2030-250, ATGP2030-500, ATGP2030-1

References & Citations

Andrusiewicz M, Szczerba A, et al. (2011) . J Transl Med. 9:130.; ; Gregor CR, Cerasoli E, et al. (2011) . J Biol Chem. 286 (28) :25016-26. ;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_000728

Uniprot Accession Number

P0DN86

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSSKEPLRP RCRPINATLA VEKEGCPVCI TVNTTICAGY CPTMTRVLQG VLPALPQVVC NYRDVRFESI RLPGCPRGVN PVVSYAVALS CQCALCRRST TDCGGPKDHP LTCDDPRFQD SSSSKAPPPS LPSPSRLPGP SDTPILPQ