Recombinant human TDP2 protein
TDP2 is a member of a superfamily of divalent cation-dependent phosphodiesterases. The protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. Recombinant human TDP2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Tyrosyl-DNA phosphodiesterase 2, AD022, dJ30M3.3, EAP2, EAPII, RP1-30M3.3, TTRAP
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
43.3 kDa (385aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Vilotti, S., et al. (2012) Cell Death Differ. 19 (3), 488-500; ; Pinel, P., et al. (2012) J. Neurosci. 32 (3), 817-825;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Cancer
NCBI Accession Number
NP_057698
Uniprot Accession Number
O95551
Species
Human
AA Sequence
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