Recombinant human CRLF2 protein

CRLF2 is a receptor for thymic stromal lymphopoietin (TSLP) . Together with the interleukin 7 receptor (IL7R), the protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene. Recombinant human CRLF2 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Cytokine receptor-like factor 2 isoform 1 precursor, CRL2, CRLF2Y, TSLPR, Cytokine receptor-like factor 2 isoform 1, CRLF2, Cytokine receptor-like 2, ILXR, Thymic stromal lymphopoietin protein receptor, TSLP receptor

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

26.6 kDa (232aa)

Additionnal Information

TSLPR, TSLP R, Cytokine receptor-like factor 2 isoform 1 precursor, CRLF2Y, CRLF2, CRL2, ATGP2022-10 µg, ATGP2022-20 µg, ATGP2022-50 µg, ATGP2022-100 µg, ATGP2022-250 µg, ATGP2022-500 µg, ATGP2022-1 mg, ATGP2022-010, ATGP2022-020, ATGP2022-050, ATGP2022-100, ATGP2022-250, ATGP2022-500, ATGP2022-01M

References & Citations

Chen, I.M., et al. (2012) Blood 119 (15), 3512-3522; ; Haslam, K., et al. (2011) Int J Lab Hematol 33 (6), E17-E19;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_071431

Uniprot Accession Number

Q9HC73

Species

Human

AA Sequence

QGGAAEG VQIQIIYFNL ETVQVTWNAS KYSRTNLTFH YRFNGDEAYD QCTNYLLQEG HTSGCLLDAE QRDDILYFSI RNGTHPVFTA SRWMVYYLKP SSPKHVRFSW HQDAVTVTCS DLSYGDLLYE VQYRSPFDTE WQSKQENTCN VTIEGLDAEK CYSFWVRVKA MEDVYGPDTY PSDWSEVTCW QRGEIRDACA ETPTPPKPKL SK