Recombinant human Follistatin/FST protein
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. Recombinant human FST protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Follistatin, Follistatin, FS, FST344
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
37 kDa (336aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Lerch T.F., et al. (2007) J. Biol. Chem. 282:15930-15939; ; Cash J.N., et al. (2009) EMBO J. 28:2662-2676;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_037541
Uniprot Accession Number
P19883
Species
Human
AA Sequence
Frequently Asked Questions
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