Recombinant human ARC protein

Activity-regulated cytoskeleton-associated protein, also known as ARC, is required for consolidation of synaptic plasticity as well as formation of long-term memory. This protein regulates endocytosis of AMPA receptors in response to synaptic activity. This protein required for homeostatic synaptic scaling of AMPA receptors. This protein plays a role in the regulation of cell morphology and cytoskeletal organization. Recombinant human ARC protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Activity-regulated cytoskeleton-associated protein, Arg3.1, KIAA0278

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

47.4 kDa (416aa) confirmed by MALDI-TOF

Additionnal Information

ARC, Activity-regulated cytoskeleton-associated protein, Arg3.1, KIAA0278, ATGP2016-10 µg, ATGP2016-20 µg, ATGP2016-50 µg, ATGP2016-100 µg, ATGP2016-250 µg, ATGP2016-500 µg, ATGP2016-1 mg, ATGP2016-10, ATGP2016-20, ATGP2016-50, ATGP2016-100, ATGP2016-250, ATGP2016-500, ATGP2016-1

References & Citations

Nagase T., et al. (1996) DNA Res. 3:321-329

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Scientific Category

Neuroscience

NCBI Accession Number

NP_056008

Uniprot Accession Number

Q7LC44

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MELDHRTSGG LHAYPGPRGG QVAKPNVILQ IGKCRAEMLE HVRRTHRHLL AEVSKQVERE LKGLHRSVGK LESNLDGYVP TSDSQRWKKS IKACLCRCQE TIANLERWVK REMHVWREVF YRLERWADRL ESTGGKYPVG SESARHTVSV GVGGPESYCH EADGYDYTVS PYAITPPPAA GELPGQEPAE AQQYQPWVPG EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS QIQNHMNGPA KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ FLWRKRDLYQ TLYVDADEEE IIQYVVGTLQ PKLKRFLRHP LPKTLEQLIQ RGMEVQDDLE QAAEPAGPHL PVEDEAETLT PAPNSESVAS DRTQPE