Recombinant human MCTS1 protein

Malignant T cell amplified sequence 1, also known as MCTS1, plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Recombinant human MCTS1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Malignant T cell amplified sequence 1, MCT-1, MCT1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

22.9 kDa (204aa) confirmed by MALDI-TOF

Additionnal Information

MCTS1, Malignant T cell amplified sequence 1, MCT-1, MCT1, ATGP1995-10 µg, ATGP1995-20 µg, ATGP1995-50 µg, ATGP1995-100 µg, ATGP1995-250 µg, ATGP1995-500 µg, ATGP1995-1 mg, ATGP1995-10, ATGP1995-20, ATGP1995-50, ATGP1995-100, ATGP1995-250, ATGP1995-500, ATGP1995-1

References & Citations

Herbert G.B., et al. (2001) Oncogene. 20:6777-6783; ; Shi B., et al. (2003) Blood. 102:297-302;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl,20% glycerol, 1mM DTT

Scientific Category

Cardiovascular

NCBI Accession Number

NP_054779

Uniprot Accession Number

Q9ULC4

Species

Human

AA Sequence

MFKKFDE KENVSNCIQL KTSVIKGIKN QLIEQFPGIE PWLNQIMPKK DPVKIVRCHE HIEILTVNGE LLFFRQREGP FYPTLRLLHK YPFILPHQQV DKGAIKFVLS GANIMCPGLT SPGAKLYPAA VDTIVAIMAE GKQHALCVGV MKMSAEDIEK VNKGIGIENI HYLNDGLWHM KTYK