Recombinant human TNRC5/CNPY3 protein
Canopy 3 homolog, also known as CNPY3, is Toll-like receptor (TLR) -specific co-chaperone for HSP90B1. This protein is required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, CNPY3i s required for both innate and adaptive immune responses. Recombinant human CNPY3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Canopy 3 homolog, CAG4A, ERDA5, PRAT4A, TNRC5
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
29.9 kDa (271aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Additionnal Information
References & Citations
Chen R., et al. (2009) J. Proteome Res. 8:651-661
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Heat Shock Proteins
NCBI Accession Number
NP_006577
Uniprot Accession Number
Q9BT09
Species
Human
AA Sequence
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