Recombinant human TACI/TNFRSF13B protein

TNFRSF13B, also known as TACI, is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system. It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML) . It was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family. It controls T cell-independent B cell antibody responses, isotype switching, and B cell homeostasis. Recombinant human TNFRSF13B protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

TNF receptor superfamily member 13B, Transmembrane activator and CAML interactor, TACI, CD267, IGAD2

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

20.9 kDa (188aa)

Additionnal Information

CD 267, CD267, CD267 antigen, CVID, CVID2, FLJ39942, IGAD2, MGC133214, MGC39952, OTTHUMP00000065442, RYZN, TACI, TNF receptor superfamily member 13B, TNFRSF 13B, TNFRSF13B, TNFRSF13B protein, TR13B_HUMAN, Transmembrane activator and CAML interactor, Tumor necrosis factor receptor 13B, Tumor necrosis factor receptor superfamily member 13B, ATGP1989-10 µg, ATGP1989-20 µg, ATGP1989-50 µg, ATGP1989-100 µg, ATGP1989-250 µg, ATGP1989-500 µg, ATGP1989-1 mg, ATGP1989-010, ATGP1989-020, ATGP1989-050, ATGP1989-100, ATGP1989-250, ATGP1989-500, ATGP1989-01M

References & Citations

Wu Y. et al. (2000) J Biol Chem. 275:35478-35485.; ; von Bulow Gu. et al. (1997) Science. 278:138-141.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea

Scientific Category

Immunology

NCBI Accession Number

NP_036584

Uniprot Accession Number

O14836

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMSGLGRS RRGGRSRVDQ EERFPQGLWT GVAMRSCPEE QYWDPLLGTC MSCKTICNHQ SQRTCAAFCR SLSCRKEQGK FYDHLLRDCI SCASICGQHP KQCAYFCENK LRSPVNLPPE LRRQRSGEVE NNSDNSGRYQ GLEHRGSEAS PALPGLKLSA DQVALVYS