Recombinant human KCTD11 protein
BTB/POZ domain-containing protein KCTD11, is a 232 amino acid regulator of neuronal differentiation that induces growth arrest, apoptosis and the expression of p27, a cyclin-dependent kinase inhibitor. Expressed at highest levels in cerebellum, KCTD11 functions as an antagonist of the Hedgehog pathway and activator of the caspase cascade. Recombinant human KCTD11 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
BTB/POZ domain-containing protein KCTD11, C17orf36, KCASH1, MGC129844, REN, REN/KCTD11
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
28 kDa (252aa)
Additionnal Information
References & Citations
Gallo R., et al. (2002) J Cell Biol. 158:731-740.; ; Di Marcotullio L., et al. (2004) Proc Natl Acad Sci uSA. 101:10833-10838.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001002914.1
Uniprot Accession Number
Q693B1
Species
Human
AA Sequence
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