Recombinant human SYT4 protein
Synaptotagmin-4, also known as SYT4, belongs to the synaptotagmin family proteins. Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. SYT4 is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus. The proximity of the SYT4 gene to markers of several psychiatric disorders suggest an involvement of SYT4 in human diseasee. Recombinant human SYT4 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Synaptotagmin-4, HsT1192, KIAA1342
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
46.1 kDa (409aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Ferguson G D., et al. (2000) J Biol Chem. 275:36920-36926.; ; Ibata K., et al. (2002) Neurosci Res. 43: 401-406.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% glycerol, 1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_065834
Uniprot Accession Number
Q9H2B2
Species
Human
AA Sequence
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