Recombinant human delta Sarcoglycan/SGCD protein
SGCD is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC) . DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. The mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed. In melanocytic cells SGCD gene expression may be regulated by MITF. Recombinant human SGCD protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Delta-sarcoglycan, 35DAG, CMD1L, DAGD, SG-delta, SGCDP, SGD, LGMD2F, Delta-SG
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
28.1 kDa (257aa)
Additionnal Information
References & Citations
Sylvius N, Duboscq-Bidot L, et al. (2003) . Am J Med Genet A. 120A (1) :8-12.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Cytoskeleton
NCBI Accession Number
NP_001121681
Uniprot Accession Number
Q92629
Species
Human
AA Sequence
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