Recombinant human AIDA protein
AIDA acts as a ventralizing factor during embryogenesis. This protein inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling. Recombinant human AIDA protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Axin interactor dorsalization-associated, C1orf80, RP11-378J18.7
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
37.4 kDa (329aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Rui, Y., et al. (2007) Dev. Cell 13 (2), 268-282
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.2M NaCl,1mM DTT
Scientific Category
Development
NCBI Accession Number
NP_073742
Uniprot Accession Number
Q96BJ3
Species
Human
AA Sequence
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