Recombinant human OB-Cadherin/CDH11 protein

CDH11, also known as cadherin 11, is a member of the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. This protein is defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. Recombinant human CDH11 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Cadherin 11 type 2, CAD11, CDHOB, OB, OSF-4, OB-cadherin (Osteoblast)

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

66.2 kDa (601aa)

Additionnal Information

CDH11, Cadherin 11 type 2, Cadherin 11, type 2, CAD11, CDHOB, OB, OSF-4, ATGP1971-10 µg, ATGP1971-20 µg, ATGP1971-50 µg, ATGP1971-100 µg, ATGP1971-250 µg, ATGP1971-500 µg, ATGP1971-1 mg, ATGP1971-10, ATGP1971-20, ATGP1971-50, ATGP1971-100, ATGP1971-250, ATGP1971-500, ATGP1971-1

References & Citations

Pishvaian MJ. et al. (1999) Cancer Res. 59:947-952.; ; Suzuki S. et al. (1991) Cell Regul. 2:261-270.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.1M NaCl

Scientific Category

Cancer

NCBI Accession Number

AAH13609.1

Uniprot Accession Number

Q96CZ9

Species

Human

AA Sequence

GWV WNQFFVIEEY TGPDPVLVGR LHSDIDSGDG NIKYILSGEG AGTIFVIDDK SGNIHATKTL DREERAQYTL MAQAVDRDTN RPLEPPSEFI VKVQDINDNP PEFLHETYHA NVPERSNVGT SVIQVTASDA DDPTYGNSAK LVYSILEGQP YFSVEAQTGI IRTALPNMDR EAKEEYHVVI QAKDMGGHMG GLSGTTKVMI TLTDVNDNPP KFPQSVYQMS VSEAAVPGEE VGRVKAKDPD IGENGLVTYN IVDGDGMESF EITTDYETQE GVIKLKKPVD FETKRAYSLK VEAANVHIDP KFISNGPFKD TVTVKIAVED ADEPPMFLAP SYIHEVQENA AAGTVVGRVH AKDPDAANSP IRYSIDRHTD LDRFFTINPE DGFIKTTKPL DREETAWLNI TVFAAEIHNR HQEAKVPVAI RVLDVNDNAP KFAAPYEGFI CESDQTKPLS NQPIVTISAD DKDDTANGPR FIFSLPPEII HNPNFTVRDN RDNTAGVYAR RGGFSRQKQD LYLLPIVISD GGIPPMSSTN TLTIKVCGCD VNGALLSCNA EAYILNAGLS T