Recombinant human HAX-1 protein

HAX1 is known to associate with HS1, a substrate of Src family tyrosine kinases. It also interacts with the product of PKD2, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with F-actin-binding protein, cortactin. It is associated with autosomal recessive severe congenital neutropenia, also known as Kostmann syndrome. Recombinant human HAX1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

HCLS1 associated protein X-1 isoform a, HCLSBP1, HS1BP1, SCN3

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 80% by SDS-PAGE

Molecular Weight

33.7 kDa (299aa) confirmed by MALDI-TOF

Additionnal Information

HAX1, HCLS1 associated protein X-1 isoform a, HCLSBP1, HS1BP1, SCN3, ATGP1969-10 µg, ATGP1969-20 µg, ATGP1969-50 µg, ATGP1969-100 µg, ATGP1969-250 µg, ATGP1969-500 µg, ATGP1969-1 mg, ATGP1969-10, ATGP1969-20, ATGP1969-50, ATGP1969-100, ATGP1969-250, ATGP1969-500, ATGP1969-1

References & Citations

Modem S. et al. (2008) J Cell Physiol. 214:14-19.; ; Klein C. et al. (2007) Nat Genet. 39:86-92.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.1M NaCl

Scientific Category

Metabolism

NCBI Accession Number

NP_006109

Uniprot Accession Number

O00165

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MSLFDLFRGF FGFPGPRSHR DPFFGGMTRD EDDDEEEEEE GGSWGRGNPR FHSPQHPPEE FGFGFSFSPG GGIRFHDNFG FDDLVRDFNS IFSDMGAWTL PSHPPELPGP ESETPGERLR EGQTLRDSML KYPDSHQPRI FGGVLESDAR SESPQPAPDW GSQRPFHRFD DVWPMDPHPR TREDNDLDSQ VSQEGLGPVL QPQPKSYFKS ISVTKITKPD GIVEERRTVV DSEGRTETTV TRHEADSSPR GDPESPRPPA LDDAFSILDL FLGRWFRSR