Recombinant human RAP2B protein
Ras-related protein Rap-2b, also known as RAP2B, belongs to a family of RAS-related genes. unlike normal ras proteins that have a nontransforming glutamine residue at aa 61, Rap2B has a threonine residue in that position. This change makes the intrinsic GTPase activity for Rap2B lower, thereby allowing it to exist in the activated state for a longer period of time than normal ras proteins. RAP2B is a platelet protein that is activated by thrombin and involved in platelet activation. RAP2B may be a novel candidate oncogene that plays important roles in carcinogenesis through activation of NF-kappaB pathway. Recombinant human RAP2B protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Ras-related protein Rap-2b, RAP2B, Member of RAS oncogene family, Small GTP binding protein, Ras family small GTP binding protein RAP2B
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
22.9 kDa (206aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Culine S., et al. (1989) Int J Cancer. 44:990-994; ; Beranger F., et al. (1991) Oncogene. 6: 1835-1842.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_002877
Uniprot Accession Number
P61225
Species
Human
AA Sequence
Frequently Asked Questions
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