Recombinant human RAB10 protein
RAB10 is a member of the Ras superfamily of small GTP-binding proteins. This protein is a key regulator of endocytic recycling, especially in the basolateral recycling pathways of polarized epithelial cells. It is required for the recruitment of CNT-1 to endosomal membranes in the intestinal epithelium. Recombinant human RAB10 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Ras-related GTP-binding protein RAB10, RAB10, RAB10 member RAS oncogene family, Ras-related protein Rab-10
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
24.7 kDa (220aa)
Additionnal Information
References & Citations
Chen Y. et al. (2012) J Cell Biol. 198:545-560.; ; Sano H. et al. (2011) J Biol Chem. 286:16541-16545.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea
Scientific Category
Signal Transduction
NCBI Accession Number
NP_057215.3
Uniprot Accession Number
P61026
Species
Human
AA Sequence
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