Recombinant human Chitinase 3-like 1/CHI3L1 protein
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. CHI3L1 is a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. This protein is thought to play a role in the process of inflammation and tissue remodeling. Recombinant human CHI3L1 protein was expressed with C-terminal myc-His-tag in CHO (chinese hamster ovary) cells using mammalian expression system and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Chitinase 3-like 1, cartilage glycoprotein-39, CGP-39; GP-39; hCGP-39, YKL40, YKL-40, YK-40, 39 kDa synovial protein, ASRT7
Expression System
CHO Cell
Antigen Species
Human
Tag
His-Myc-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
43.3 kDa (387aa)
Additionnal Information
References & Citations
Kazakova MH. et al. (2009) Folia Med. 51:5-14.; ; Bonneh-Barkay D. et al. (2008) Am J Pathol. 173:130-143.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4)
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001267
Uniprot Accession Number
P36222
Species
Human
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