Recombinant human DNAL1 protein

DNAL1 is an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. DNAL1 is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants. Recombinant human DNAL1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Dynein light chain 1 axonemal, Dynein light chain 1, axonemal, C14orf168, CILD16

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

23.9 kDa (213aa)

Additionnal Information

DNAL1, Dynein light chain 1 axonemal, Dynein light chain 1, axonemal, C14orf168, CILD16, ATGP1958-10 µg, ATGP1958-20 µg, ATGP1958-50 µg, ATGP1958-100 µg, ATGP1958-250 µg, ATGP1958-500 µg, ATGP1958-1 mg, ATGP1958-10, ATGP1958-20, ATGP1958-50, ATGP1958-100, ATGP1958-250, ATGP1958-500, ATGP1958-1

References & Citations

Horvath J, Fliegauf M, et al. (2005) . Am J Respir Cell Mol Biol. 33 (1) :41-7.; ; Lancaster MA, et al. (2009) . Curr Opin Genet Dev. 19 (3) :220-9.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Cytoskeleton

NCBI Accession Number

NP_113615

Uniprot Accession Number

Q4LDG9

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMAKATTI KEALARWEEK TGQRPSEAKE IKLYAQIPPI EKMDASLSML ANCEKLSLST NCIEKIANLN GLKNLRILSL GRNNIKNLNG LEAVGDTLEE LWISYNFIEK LKGIHIMKKL KILYMSNNLV KDWAEFVKLA ELPCLEDLVF VGNPLEEKHS AENNWIEEAT KRVPKLKKLD GTPVIKGDEE EDN