Recombinant human MXD3 protein

MXD3 is a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described. Recombinant human MXD3 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Max dimerization protein 3, BHLHC13, MAD3, MYX

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

25.9 kDa (229aa)

Additionnal Information

MXD3, Max dimerization protein 3, BHLHC13, MAD3, MYX, ATGP1957-10 µg, ATGP1957-20 µg, ATGP1957-50 µg, ATGP1957-100 µg, ATGP1957-250 µg, ATGP1957-500 µg, ATGP1957-1 mg, ATGP1957-10, ATGP1957-20, ATGP1957-50, ATGP1957-100, ATGP1957-250, ATGP1957-500, ATGP1957-1

References & Citations

Yun JS, Rust JM, et al. (2007) . Mol Cell Biol. 27 (23) :8178-89.; ; Barisone GA, Yun JS, et al. (2008) . Cell Cycle. 7 (4) :423-7.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_112590

Uniprot Accession Number

Q9BW11

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMEPLASN IQVLLQAAEF LERREREAEH GYASLCPHRS PGPIHRRKKR PPQAPGAQDS GRSVHNELEK RRRAQLKRCL ERLKQQMPLG ADCARYTTLS LLRRARMHIQ KLEDQEQRAR QLKERLRSKQ QSLQRQLEQL RGLAGAAERE RLRADSLDSS GLSSERSDSD QEELEVDVES LVFGGEAELL RGFVAGQEHS YSHGGGAWL