Recombinant human MAVS protein

Mitochondrial antiviral signaling protein, also known as MAVS, is required for innate immune defense against viruses. This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Recombinant human MAVS protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Mitochondrial antiviral signaling protein, CARDIF, IPS-1, IPS1, VISA

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

55.9 kDa (536aa)

Additionnal Information

MAVS, Mitochondrial antiviral signaling protein, CARDIF, IPS-1, IPS1, VISA, ATGP1947-10 µg, ATGP1947-20 µg, ATGP1947-50 µg, ATGP1947-100 µg, ATGP1947-250 µg, ATGP1947-500 µg, ATGP1947-1 mg, ATGP1947-10, ATGP1947-20, ATGP1947-50, ATGP1947-100, ATGP1947-250, ATGP1947-500, ATGP1947-1

References & Citations

Seth R.B., et al. (2005) Cell. 122:669-682; ; Xu L.-G., et al. (2005) Mol. Cell. 19:727-740

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Scientific Category

Immunology

NCBI Accession Number

NP_065797.2

Uniprot Accession Number

Q7Z434

Species

Human

AA Sequence

MPFAEDK TYKYICRNFS NFCNVDVVEI LPYLPCLTAR DQDRLRATCT LSGNRDTLWH LFNTLQRRPG WVEYFIAALR GCELVDLADE VASVYQSYQP RTSDRPPDPL EPPSLPAERP GPPTPAAAHS IPYNSCREKE PSYPMPVQET QAPESPGENS EQALQTLSPR AIPRNPDGGP LESSSDLAAL SPLTSSGHQE QDTELGSTHT AGATSSLTPS RGPVSPSVSF QPLARSTPRA SRLPGPTGSV VSTGTSFSSS SPGLASAGAA EGKQGAESDQ AEPIICSSGA EAPANSLPSK VPTTLMPVNT VALKVPANPA SVSTVPSKLP TSSKPPGAVP SNALTNPAPS KLPINSTRAG MVPSKVPTSM VLTKVSASTV PTDGSSRNEE TPAAPTPAGA TGGSSAWLDS SSENRGLGSE LSKPGVLASQ VDSPFSGCFE DLAISASTSL GMGPCHGPEE NEYKSEGTFG IHVAENPSIQ LLEGNPGPPA DPDGGPRPQA DRKFQEREVP CHRPSP