Recombinant human IL-18BP protein
IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Recombinant human IL18BP protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Interleukin-18-binding protein, IL18BPa, Interleukin-18-binding protein isoform, IL18BP, Tadekinig-alfa
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
20 kDa (187aa)
Additionnal Information
References & Citations
Shimizu, C., et al. (2012) Mod Rheumatol 22 (1), 73-79; ; Fujita, T., et al. (2011) Diabetes Res. Clin. Pract. 92 (3), E66-E69
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001138529
Uniprot Accession Number
O95998
Species
Human
AA Sequence
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