Recombinant human IL-18BP protein

IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Recombinant human IL18BP protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Interleukin-18-binding protein, IL18BPa, Interleukin-18-binding protein isoform, IL18BP, Tadekinig-alfa

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

20 kDa (187aa)

Additionnal Information

Interleukin-18 binding protein, Interleukin 18 binding protein, Interleukin-18-binding protein, IL18BPa, Interleukin 18 binding protein isoform, Interleukin-18-binding protein isoform, Interleukin18 binding protein isoform, IL18BP, Tadekinig-alfa, Tadekinig alfa, ATGP1940-10 µg, ATGP1940-20 µg, ATGP1940-50 µg, ATGP1940-100 µg, ATGP1940-250 µg, ATGP1940-500 µg, ATGP1940-1 mg, ATGP1940-010, ATGP1940-020, ATGP1940-050, ATGP1940-100, ATGP1940-250, ATGP1940-500, ATGP1940-01M

References & Citations

Shimizu, C., et al. (2012) Mod Rheumatol 22 (1), 73-79; ; Fujita, T., et al. (2011) Diabetes Res. Clin. Pract. 92 (3), E66-E69

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_001138529

Uniprot Accession Number

O95998

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSTPVSQTT TAATASVRST KDPCPSQPPV FPAAKQCPAL EVTWPEVEVP LNGTLSLSCV ACSRFPNFSI LYWLGNGSFI EHLPGRLWEG STSRERGSTG TQLCKALVLE QLTPALHSTN FSCVLVDPEQ VVQRHVVLAQ LWAGLRATLP PTQEALPSSH SSPQQQG