Recombinant human XPA protein

XPA, also known as DNA repair protein complementing XP-A cells, belong to the XPA family. This protein is involved in DNA excision repair. It Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Defects in XPA are a cause of xeroderma pigmentosum complementation group A (XP-A), which is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Recombinant human XPA protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

DNA repair protein complementing XP-A cells, XP1, XPAC

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

33.8 kDa (296aa)

Additionnal Information

XPA, DNA repair protein complementing XP-A cells, XP1, XPAC, ATGP1932-10 µg, ATGP1932-20 µg, ATGP1932-50 µg, ATGP1932-100 µg, ATGP1932-250 µg, ATGP1932-500 µg, ATGP1932-1 mg, ATGP1932-10, ATGP1932-20, ATGP1932-50, ATGP1932-100, ATGP1932-250, ATGP1932-500, ATGP1932-1

References & Citations

Pan Y.R., et al. (2009) Cell Cycle 8:655-664; ; James, et al. (2005) Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.) . Saunders.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_000371

Uniprot Accession Number

P23025

Species

Human

AA Sequence

MAAADGA LPEAAALEQP AELPASVRAS IERKRQRALM LRQARLAARP YSATAAAATG GMANVKAAPK IIDTGGGFIL EEEEEEEQKI GKVVHQPGPV MEFDYVICEE CGKEFMDSYL MNHFDLPTCD NCRDADDKHK LITKTEAKQE YLLKDCDLEK REPPLKFIVK KNPHHSQWGD MKLYLKLQIV KRSLEVWGSQ EALEEAKEVR QENREKMKQK KFDKKVKELR RAVRSSVWKR ETIVHQHEYG PEENLEDDMY RKTCTMCGHE LTYEKM