Recombinant human Lyn protein
Tyrosine-protein kinase Lyn, also known as LYN, is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. This protein is Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. It Induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents. Recombinant human LYN protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Tyrosine-protein kinase Lyn, JTK8, p53Lyn, p56Lyn
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
61.0 kDa (535aa)
Additionnal Information
References & Citations
Gaul B.S., et al. (2001) J. Biol. Chem. Res. 275:16174-16182; ; Rena G., et al. (2001) Mol. Pharmacol. 59:996-1011
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_002341
Uniprot Accession Number
P07948
Species
Human
AA Sequence
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