Recombinant human USAG1 protein

SOSTDC1 is a member of the sclerostin family and an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. Recombinant human SOSTDC1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Sclerostin domain-containing protein 1, CDA019, ECTODIN, uSAG1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

23 kDa (206aa)

Additionnal Information

USAG1, Sclerostin domain-containing protein 1, CDA019, ECTODIN, uSAG1, ATGP1905-10 µg, ATGP1905-20 µg, ATGP1905-50 µg, ATGP1905-100 µg, ATGP1905-250 µg, ATGP1905-500 µg, ATGP1905-1 mg, ATGP1905-10, ATGP1905-20, ATGP1905-50, ATGP1905-100, ATGP1905-250, ATGP1905-500, ATGP1905-1

References & Citations

Yanagita M, Oka M, et al. (2004) . Biochem Biophys Res Commun. 316 (2) :490-500.; ; Goto M, et al. (2004) . J Biol Chem. 279 (40) :42128-38.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Signal Transduction

NCBI Accession Number

NP_056279

Uniprot Accession Number

Q6X4U4

Species

Human

AA Sequence

FKNDATE ILYSHVVKPV PAHPSSNSTL NQARNGGRHF SNTGLDRNTR VQVGCRELRS TKYISDGQCT SISPLKELVC AGECLPLPVL PNWIGGGYGT KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG STRTYKITVV TACKCKRYTR QHNESSHNFE SMSPAKPVQH HRERKRASKS SKHSMS