Recombinant human UPK2 protein
UPK2 is one of the proteins of the highly urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. This protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas. Recombinant human uPK2 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Uroplakin-2, uP2, uPII
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
16.2 kDa (153aa)
Additionnal Information
References & Citations
Jenkins, D., et al. (2006) Nephrol. Dial. Transplant. 21 (12), 3415-3421
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M uREA, 10% glycerol
Scientific Category
Differentiation & Regeneration
NCBI Accession Number
NP_006751.1
Uniprot Accession Number
O00526
Species
Human
AA Sequence
DFNISSL SGLLSPALTE SLLVALPPCH LTGGNATLMV RRANDSKVVT SSFVVPPCRG RRELVSVVDS GAGFTVTRLS AYQVTNLVPG TKFYISYLVK KGTATESSRE IPMSTLPRRN MESIGLGMAR TGG
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