Recombinant human SDHAF2 protein
SDHAF2 is a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Defects in SDHAF2 are the cause of hereditary paragangliomas type 2 (PGL2), also known as familial non-chromaffin paragangliomas type 2. Paragangliomas refer to rare and mostly benign tumors that arise from any component of the neuroendocrine system. Recombinant human SDHAF2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Succinate dehydrogenase assembly factor 2 mitochondrial, Succinate dehydrogenase assembly factor 2, mitochondrial, C11orf79, PGL2, SDH5
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
19kDa (160aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Kunst, H.P., et al. (2011) Clin. Cancer Res. 17 (2), 247-254; ; Starker, L.F., et al. (2010) Endocrine 38 (3), 397-401
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 30% glycerol, 1mM DTT
Scientific Category
Metabolism
NCBI Accession Number
NP_060311
Uniprot Accession Number
Q9NX18
Species
Human
AA Sequence
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