Recombinant human Inhibin A protein

INHA, also known as Inhibin alpha, belongs to the TGF-beta family. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Recombinant human INHA protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Inhibin alpha chain, A inhibin subunit precursor, IHA

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

17 kDa (155aa)

Additionnal Information

Inhibin A, inhibin alpha chain, A inhibin subunit precursor, IHA, ATGP1898-10 µg, ATGP1898-20 µg, ATGP1898-50 µg, ATGP1898-100 µg, ATGP1898-250 µg, ATGP1898-500 µg, ATGP1898-1 mg, ATGP1898-10, ATGP1898-20, ATGP1898-50, ATGP1898-100, ATGP1898-250, ATGP1898-500, ATGP1898-1

References & Citations

Knight, P.G. (1996) Front. Neuroendocrinol. 17: 476-509.; ; Mather, J.P., et al. (1997) . Proc. Soc. Exp. Biol. Med. 215: 209-222.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Signal Transduction

NCBI Accession Number

NP_002182

Uniprot Accession Number

P05111

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MSTPLMSWPW SPSALRLLQR PPEEPAAHAN CHRVALNISF QELGWERWIV YPPSFIFHYC HGGCGLHIPP NLSLPVPGAP PTPAQPYSLL PGAQPCCAAL PGTMRPLHVR TTSDGGYSFK YETVPNLLTQ HCACI