Recombinant human IMPAD1 protein
Inositol monophosphatase 3, also known as IMPAD1, is a member of the inositol monophosphatase family. IMPAD1 is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP) . Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1. Recombinant human IMPAD1 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Inositol monophosphatase 3, GPAPP, IMP 3, IMP-3, IMPA3
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
37.6 kDa (349aa)
Additionnal Information
References & Citations
Vissers L E., et al. (2011) Am J Hum Genet. 88 (5) :608-15.; ; Kalujnaia S., et al. (2010) FASEB J. 24 (10) :3981-91.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M urea, 20% glycerol
Scientific Category
Metabolism
NCBI Accession Number
NP_060283
Uniprot Accession Number
Q9NX62
Species
Human
AA Sequence
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