Recombinant human SLAM/CD150 protein
SLAMF1 belongs to the immunoglobulin gene superfamily and is involved in T-cell stimulation. This protein is constitutively expressed on peripheral blood memory T cells, T-cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. High-affinity for self-ligand is important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11) -dependent signal transduction operates. Recombinant human SLAMF1 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Signaling lymphocytic activation molecule precursor, CD150, CDw150, SLAM
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
26.7 kDa (240aa)
Additionnal Information
References & Citations
Frecha, C., et al. (2011) J. Virol. 85 (12), 5975-5985 ; ; Jordan, M.A., et al. (2011) . Immunol. 186 (7), 3953-3965;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol
Scientific Category
Stem Cell
NCBI Accession Number
NP_003028
Uniprot Accession Number
Q13291
Species
Human
AA Sequence
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