Recombinant human SLAM/CD150 protein
SLAMF1 belongs to the immunoglobulin gene superfamily and is involved in T-cell stimulation. This protein is constitutively expressed on peripheral blood memory T cells, T-cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. High-affinity for self-ligand is important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11) -dependent signal transduction operates. Recombinant human SLAMF1 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Signaling lymphocytic activation molecule precursor, CD150, CDw150, SLAM
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
26.7 kDa (240aa)
Additionnal Information
References & Citations
Frecha, C., et al. (2011) J. Virol. 85 (12), 5975-5985 ; ; Jordan, M.A., et al. (2011) . Immunol. 186 (7), 3953-3965;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol
Scientific Category
Stem Cell
NCBI Accession Number
NP_003028
Uniprot Accession Number
Q13291
Species
Human
AA Sequence
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Recombinant Pectobacterium carotovorum subsp. carotovorum Membrane protein insertase YidC (yidC)
Recombinant Pectobacterium carotovorum subsp. carotovorum Membrane protein insertase YidC (yidC)
ADAM 17, Control Peptide (Disintegrin and Metalloproteinase Domain-containing Protein 17, Snake Venom-like Protease, TNF-alpha Convertase, TNF-alpha-converting Enzyme, CD156b, CSVP, TACE, ADAM17, MGC71942)