Recombinant human NKX3.1 protein

NKX3-1 is a homeobox-containing transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of NKX3-1 is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this. Recombinant human NKX3-1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Homeobox protein Nkx-3.1, BAPX2, NKX3, NKX3.1, NKX3A, NKX3-1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

28.7 kDa (257aa)

Additionnal Information

NKX3.1, Homeobox protein Nkx-3.1, BAPX2, NKX3, NKX3.1, NKX3A, ATGP1882-10 µg, ATGP1882-20 µg, ATGP1882-50 µg, ATGP1882-100 µg, ATGP1882-250 µg, ATGP1882-500 µg, ATGP1882-1 mg, ATGP1882-10, ATGP1882-20, ATGP1882-50, ATGP1882-100, ATGP1882-250, ATGP1882-500, ATGP1882-1

References & Citations

Anderson, P.D., et al. (2012) . Clin. Invest. 122 (5), 1907-1919; ; Tan, P.Y., et al. (2012) Mol. Cell. Biol. 32 (2), 399-414;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M UREA, 10% glycerol

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_006158

Uniprot Accession Number

Q99801

Species

Human

AA Sequence

MLRVPEP RPGEAKAEGA APPTPSKPLT SFLIQDILRD GAQRQGGRTS SQRQRDPEPE PEPEPEGGRS RAGAQNDQLS TGPRAAPEEA ETLAETEPER HLGSYLLDSE NTSGALPRLP QTPKQPQKRS RAAFSHTQVI ELERKFSHQK YLSAPERAHL AKNLKLTETQ VKIWFQNRRY KTKRKQLSSE LGDLEKHSSL PALKEEAFSR ASLVSVYNSY PYYPYLYCVG SWSPAFW