Recombinant human Complement Factor D protein
CFD, also known as adipsin, is involved in the alternative complement pathway of the complement system where it cleaves factor B. This protein is a member of the trypsin family of peptidases. It is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. It is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, it has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. Recombinant human CFD protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Complement factor D, DF, AND, PFD, ADIPSIN
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
26.6 kDa (249aa)
Additionnal Information
References & Citations
Narayana SV. et al. (1994) J Mol Biol. 235:695-708.; ; Ronti T. et al. (2006) Clin Endocrinol (Oxf) . 64:355-365.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea
Scientific Category
Immunology
NCBI Accession Number
NP_001919
Uniprot Accession Number
P00746
Species
Human
AA Sequence
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