Recombinant human TIM-3/HAVCR2 protein

HAVCR2, also known as TIM3, belongs to the immunoglobulin superfamily. HACVR2 regulates macrophage activation. It Inhibits T-helper type 1 lymphocyte (Th1) -mediated auto- and alloimmune responses and promotes immunological tolerance. Recombinant human HAVCR2 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Hepatitis A virus cellular receptor 2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3, CD366

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

22.7 kDa (206aa)

Additionnal Information

CD366, Hepatitis A virus cellular receptor 2, T cell immunoglobulin and mucin domain containing protein 3, T cell immunoglobulin mucin receptor 3, T cell membrane protein 3, T-cell immunoglobulin and mucin domain containing protein 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIM 3, TIM3, TIM-3, TIMD 3, TIMD3, TIMD-3, ATGP1875-10 µg, ATGP1875-20 µg, ATGP1875-50 µg, ATGP1875-100 µg, ATGP1875-250 µg, ATGP1875-500 µg, ATGP1875-1 mg, ATGP1875-010, ATGP1875-020, ATGP1875-050, ATGP1875-100, ATGP1875-250, ATGP1875-500, ATGP1875-01M

References & Citations

Sanchez-Fueyo A., et al. (2003) Nat. Immunol. 4:1093-1101; ; Zhu C., et al. (2005) Nat. Immunol. 6:1245-1252;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

AAH63431

Uniprot Accession Number

Q8TDQ0

Species

Human

AA Sequence

SEVEY RAEVGQNAYL PCFYTPAAPG NLVPVCWGKG ACPVFECGNV VLRTDERDVN YWTSRYWLNG DFRKGDVSLT IENVTLADSG IYCCRIQIPG IMNDEKFNLK LVIKPAKVTP APTLQRDFTA AFPRMLTTRG HGPAETQTLG SLPDINLTQI STLANELRDS RLANDLRDSG ATIRIG