Recombinant human Endocan/ESM1 protein
Endothelial cell-specific molecule 1, also known as ESM1, is a proteoglycan secreted by endothelial cells and its mRNA expression is regulated by inflammatory cytokines. ESM1 expression has also been detected in different epithelia and in adipocytes. The expression of endocan is upregulated by TNF alpha, IL1 beta, or lipopolysaccharide and downregulated by IFN gamma. Genetically engineered cells overexpressing endocan has been shown to induce tumor formation, suggesting that ESM1 may be involved in the pathophysiology of tumor growth in vivo. Recombinant human ESM1 protein, fused to His-tag at N-terminus, was expressed in E. coli
Product Specifications
Product Name Alternative
Endocan, Endothelial cell-specific molecule 1, Endothelial cell-specific molecule 1 isoform a, ESM1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
20.5 kDa (188aa)
Additionnal Information
References & Citations
Scherpereel A., et al. (2003) Cancer Res. 63:6084.; ; Bechard D., et al. (2000) J Vasc Res. 37:417.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M urea, 10% glycerol
Scientific Category
Angiogenesis
NCBI Accession Number
NP_008967.1
Uniprot Accession Number
Q9NQ30
Species
Human
AA Sequence
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