Recombinant human Endocan/ESM1 protein

Endothelial cell-specific molecule 1, also known as ESM1, is a proteoglycan secreted by endothelial cells and its mRNA expression is regulated by inflammatory cytokines. ESM1 expression has also been detected in different epithelia and in adipocytes. The expression of endocan is upregulated by TNF alpha, IL1 beta, or lipopolysaccharide and downregulated by IFN gamma. Genetically engineered cells overexpressing endocan has been shown to induce tumor formation, suggesting that ESM1 may be involved in the pathophysiology of tumor growth in vivo. Recombinant human ESM1 protein, fused to His-tag at N-terminus, was expressed in E. coli

Product Specifications

Product Name Alternative

Endocan, Endothelial cell-specific molecule 1, Endothelial cell-specific molecule 1 isoform a, ESM1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

20.5 kDa (188aa)

Additionnal Information

Endocan, Endothelial cell-specific molecule 1, Endothelial cell-specific molecule 1 isoform a, ESM1, ATGP1864-10 µg, ATGP1864-20 µg, ATGP1864-50 µg, ATGP1864-100 µg, ATGP1864-250 µg, ATGP1864-500 µg, ATGP1864-1 mg, ATGP1864-010, ATGP1864-020, ATGP1864-050, ATGP1864-100, ATGP1864-250, ATGP1864-500, ATGP1864-01M

References & Citations

Scherpereel A., et al. (2003) Cancer Res. 63:6084.; ; Bechard D., et al. (2000) J Vasc Res. 37:417.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M urea, 10% glycerol

Scientific Category

Angiogenesis

NCBI Accession Number

NP_008967.1

Uniprot Accession Number

Q9NQ30

Species

Human

AA Sequence

WSNNYAV DCPQHCDSSE CKSSPRCKRT VLDDCGCCRV CAAGRGETCY RTVSGMDGMK CGPGLRCQPS NGEDPFGEEF GICKDCPYGT FGMDCRETCN CQSGICDRGT GKCLKFPFFQ YSVTKSSNRF VSLTEHDMAS GDGNIVREEV VKENAAGSPV MRKWLNPR