Recombinant human Relaxin-2 protein
Prorelaxin H2, also known as RLN2, belongs to the insulin gene superfamily. This family is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. RLN2 is a peptide hormone associated with a number of therapeutically relevant physiological effects, including regulation of collagen metabolism and multiple vascular control pathways. RLN1 and RLN2 share high sequence homology. Recombinant human RLN2 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Prorelaxin H2 isoform, bA12D24.1.1, bA12D24.1.2, H2, RLXH2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
20.7 kDa (184aa)
Additionnal Information
References & Citations
Hossain M A., et al. (2011) J Biol Chem. 286 (43) :37555-65.; ; Svendsen A M., et al. (2008) Mol Cell Endocrinol. 296:10-7.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_604390
Uniprot Accession Number
P04090
Species
Human
AA Sequence
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